ChloroquineV1, Main, Exploration, bibRecord, 000C28

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.

Identifieur interne : 000C28 ( Main/Exploration ); précédent : 000C27; suivant : 000C29

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.

Auteurs : Xinxin Song [États-Unis] ; Shan Zhu [République populaire de Chine] ; Yangchun Xie [États-Unis] ; Jiao Liu [République populaire de Chine] ; Lingyi Sun [États-Unis] ; Dexing Zeng [États-Unis] ; Pengcheng Wang [États-Unis] ; Xiaochao Ma [États-Unis] ; Guido Kroemer [Suède] ; David L. Bartlett [États-Unis] ; Timothy R. Billiar [États-Unis] ; Michael T. Lotze [États-Unis] ; Herbert J. Zeh [États-Unis] ; Rui Kang [États-Unis] ; Daolin Tang [États-Unis]

Source :

Gastroenterology [ 1528-0012 ] ; 2018.

RBID : pubmed:29248440

Descripteurs français

English descriptors

KwdEn :
- Adenocarcinoma (drug therapy), Adenocarcinoma (genetics), Adenocarcinoma (metabolism), Adenocarcinoma (secondary), Aminoquinolines (pharmacology), Animals, Antigens, Neoplasm (metabolism), Antineoplastic Agents (pharmacology), Benzamides (pharmacology), Biomarkers, Tumor (genetics), Biomarkers, Tumor (metabolism), Carbonic Anhydrase IX (metabolism), Cell Death (drug effects), Dose-Response Relationship, Drug, Female, Gene Expression Regulation, Neoplastic, HCT116 Cells, Humans, Hydrogen-Ion Concentration, Mice, Inbred C57BL, Mice, Nude, NF-kappa B (metabolism), Neoplastic Stem Cells (drug effects), Neoplastic Stem Cells (metabolism), Neoplastic Stem Cells (pathology), Pancreatic Neoplasms (drug therapy), Pancreatic Neoplasms (genetics), Pancreatic Neoplasms (metabolism), Pancreatic Neoplasms (pathology), Signal Transduction (drug effects), Time Factors, Tumor Burden (drug effects), Tumor Microenvironment, Xenograft Model Antitumor Assays.
MESH :
- chemical , genetics : Biomarkers, Tumor.
- chemical , metabolism : Antigens, Neoplasm, Biomarkers, Tumor, Carbonic Anhydrase IX, NF-kappa B.
- chemical , pharmacology : Aminoquinolines, Antineoplastic Agents, Benzamides.
- drug effects : Cell Death, Neoplastic Stem Cells, Signal Transduction, Tumor Burden.
- drug therapy : Adenocarcinoma, Pancreatic Neoplasms.
- genetics : Adenocarcinoma, Pancreatic Neoplasms.
- metabolism : Adenocarcinoma, Neoplastic Stem Cells, Pancreatic Neoplasms.
- pathology : Neoplastic Stem Cells, Pancreatic Neoplasms.
- secondary : Adenocarcinoma.
- Animals, Dose-Response Relationship, Drug, Female, Gene Expression Regulation, Neoplastic, HCT116 Cells, Humans, Hydrogen-Ion Concentration, Mice, Inbred C57BL, Mice, Nude, Time Factors, Tumor Microenvironment, Xenograft Model Antitumor Assays.

Abstract

Maintenance of acid-base homeostasis is required for normal physiology, metabolism, and development. It is not clear how cell death is activated in response to changes in pH. We performed a screen to identify agents that induce cell death in a pH-dependent manner (we call this alkaliptosis) in pancreatic ductal adenocarcinoma cancer (PDAC) cells and tested their effects in mice.

DOI: 10.1053/j.gastro.2017.12.004
PubMed: 29248440

Affiliations:

Le document en format XML

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<author><name sortKey="Kang, Rui" sort="Kang, Rui" uniqKey="Kang R" first="Rui" last="Kang">Rui Kang</name>
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<author><name sortKey="Tang, Daolin" sort="Tang, Daolin" uniqKey="Tang D" first="Daolin" last="Tang">Daolin Tang</name>
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<country xml:lang="fr">États-Unis</country>
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</author>
</analytic>
<series><title level="j">Gastroenterology</title>
<idno type="eISSN">1528-0012</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (drug therapy)</term>
<term>Adenocarcinoma (genetics)</term>
<term>Adenocarcinoma (metabolism)</term>
<term>Adenocarcinoma (secondary)</term>
<term>Aminoquinolines (pharmacology)</term>
<term>Animals</term>
<term>Antigens, Neoplasm (metabolism)</term>
<term>Antineoplastic Agents (pharmacology)</term>
<term>Benzamides (pharmacology)</term>
<term>Biomarkers, Tumor (genetics)</term>
<term>Biomarkers, Tumor (metabolism)</term>
<term>Carbonic Anhydrase IX (metabolism)</term>
<term>Cell Death (drug effects)</term>
<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>HCT116 Cells</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Nude</term>
<term>NF-kappa B (metabolism)</term>
<term>Neoplastic Stem Cells (drug effects)</term>
<term>Neoplastic Stem Cells (metabolism)</term>
<term>Neoplastic Stem Cells (pathology)</term>
<term>Pancreatic Neoplasms (drug therapy)</term>
<term>Pancreatic Neoplasms (genetics)</term>
<term>Pancreatic Neoplasms (metabolism)</term>
<term>Pancreatic Neoplasms (pathology)</term>
<term>Signal Transduction (drug effects)</term>
<term>Time Factors</term>
<term>Tumor Burden (drug effects)</term>
<term>Tumor Microenvironment</term>
<term>Xenograft Model Antitumor Assays</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adénocarcinome (génétique)</term>
<term>Adénocarcinome (métabolisme)</term>
<term>Adénocarcinome (secondaire)</term>
<term>Adénocarcinome (traitement médicamenteux)</term>
<term>Aminoquinoléines (pharmacologie)</term>
<term>Animaux</term>
<term>Antigènes néoplasiques (métabolisme)</term>
<term>Antinéoplasiques (pharmacologie)</term>
<term>Benzamides (pharmacologie)</term>
<term>Carbonic anhydrase IX (métabolisme)</term>
<term>Cellules HCT116</term>
<term>Cellules souches tumorales ()</term>
<term>Cellules souches tumorales (anatomopathologie)</term>
<term>Cellules souches tumorales (métabolisme)</term>
<term>Charge tumorale ()</term>
<term>Concentration en ions d'hydrogène</term>
<term>Facteur de transcription NF-kappa B (métabolisme)</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Marqueurs biologiques tumoraux (génétique)</term>
<term>Marqueurs biologiques tumoraux (métabolisme)</term>
<term>Microenvironnement tumoral</term>
<term>Mort cellulaire ()</term>
<term>Relation dose-effet des médicaments</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Souris de lignée C57BL</term>
<term>Souris nude</term>
<term>Tests d'activité antitumorale sur modèle de xénogreffe</term>
<term>Transduction du signal ()</term>
<term>Tumeurs du pancréas (anatomopathologie)</term>
<term>Tumeurs du pancréas (génétique)</term>
<term>Tumeurs du pancréas (métabolisme)</term>
<term>Tumeurs du pancréas (traitement médicamenteux)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Biomarkers, Tumor</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, Neoplasm</term>
<term>Biomarkers, Tumor</term>
<term>Carbonic Anhydrase IX</term>
<term>NF-kappa B</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Aminoquinolines</term>
<term>Antineoplastic Agents</term>
<term>Benzamides</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules souches tumorales</term>
<term>Tumeurs du pancréas</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Death</term>
<term>Neoplastic Stem Cells</term>
<term>Signal Transduction</term>
<term>Tumor Burden</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Adenocarcinoma</term>
<term>Pancreatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenocarcinoma</term>
<term>Pancreatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénocarcinome</term>
<term>Marqueurs biologiques tumoraux</term>
<term>Tumeurs du pancréas</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adenocarcinoma</term>
<term>Neoplastic Stem Cells</term>
<term>Pancreatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adénocarcinome</term>
<term>Antigènes néoplasiques</term>
<term>Carbonic anhydrase IX</term>
<term>Cellules souches tumorales</term>
<term>Facteur de transcription NF-kappa B</term>
<term>Marqueurs biologiques tumoraux</term>
<term>Tumeurs du pancréas</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neoplastic Stem Cells</term>
<term>Pancreatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Aminoquinoléines</term>
<term>Antinéoplasiques</term>
<term>Benzamides</term>
</keywords>
<keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Adénocarcinome</term>
</keywords>
<keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Adenocarcinoma</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Adénocarcinome</term>
<term>Tumeurs du pancréas</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>HCT116 Cells</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Nude</term>
<term>Time Factors</term>
<term>Tumor Microenvironment</term>
<term>Xenograft Model Antitumor Assays</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules HCT116</term>
<term>Cellules souches tumorales</term>
<term>Charge tumorale</term>
<term>Concentration en ions d'hydrogène</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Microenvironnement tumoral</term>
<term>Mort cellulaire</term>
<term>Relation dose-effet des médicaments</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Souris de lignée C57BL</term>
<term>Souris nude</term>
<term>Tests d'activité antitumorale sur modèle de xénogreffe</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Maintenance of acid-base homeostasis is required for normal physiology, metabolism, and development. It is not clear how cell death is activated in response to changes in pH. We performed a screen to identify agents that induce cell death in a pH-dependent manner (we call this alkaliptosis) in pancreatic ductal adenocarcinoma cancer (PDAC) cells and tested their effects in mice.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
<li>Svealand</li>
</region>
<settlement><li>Stockholm</li>
</settlement>
<orgName><li>Université Paris-Descartes</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Song, Xinxin" sort="Song, Xinxin" uniqKey="Song X" first="Xinxin" last="Song">Xinxin Song</name>
</region>
<name sortKey="Bartlett, David L" sort="Bartlett, David L" uniqKey="Bartlett D" first="David L" last="Bartlett">David L. Bartlett</name>
<name sortKey="Billiar, Timothy R" sort="Billiar, Timothy R" uniqKey="Billiar T" first="Timothy R" last="Billiar">Timothy R. Billiar</name>
<name sortKey="Kang, Rui" sort="Kang, Rui" uniqKey="Kang R" first="Rui" last="Kang">Rui Kang</name>
<name sortKey="Lotze, Michael T" sort="Lotze, Michael T" uniqKey="Lotze M" first="Michael T" last="Lotze">Michael T. Lotze</name>
<name sortKey="Ma, Xiaochao" sort="Ma, Xiaochao" uniqKey="Ma X" first="Xiaochao" last="Ma">Xiaochao Ma</name>
<name sortKey="Sun, Lingyi" sort="Sun, Lingyi" uniqKey="Sun L" first="Lingyi" last="Sun">Lingyi Sun</name>
<name sortKey="Tang, Daolin" sort="Tang, Daolin" uniqKey="Tang D" first="Daolin" last="Tang">Daolin Tang</name>
<name sortKey="Wang, Pengcheng" sort="Wang, Pengcheng" uniqKey="Wang P" first="Pengcheng" last="Wang">Pengcheng Wang</name>
<name sortKey="Xie, Yangchun" sort="Xie, Yangchun" uniqKey="Xie Y" first="Yangchun" last="Xie">Yangchun Xie</name>
<name sortKey="Zeh, Herbert J" sort="Zeh, Herbert J" uniqKey="Zeh H" first="Herbert J" last="Zeh">Herbert J. Zeh</name>
<name sortKey="Zeng, Dexing" sort="Zeng, Dexing" uniqKey="Zeng D" first="Dexing" last="Zeng">Dexing Zeng</name>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="Zhu, Shan" sort="Zhu, Shan" uniqKey="Zhu S" first="Shan" last="Zhu">Shan Zhu</name>
</noRegion>
<name sortKey="Liu, Jiao" sort="Liu, Jiao" uniqKey="Liu J" first="Jiao" last="Liu">Jiao Liu</name>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name>
</region>
</country>
</tree>
</affiliations>
</record>

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JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.

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